I think they can play the bones of the likely championship first XV and still have room to try a couple of things - e.g., give O'Connor another start to see if he has found his form, give Barret a chance to build his confidence. If those players are both in form, I would expect at least one to start come championship, especially factoring in the injuries and the physical toll the round robin is likely to take. You'd certainly be hoping they could at the v least be options off the bench, and come championship that will be as important as a settled first team imo.
That said, if they are in championship mode as you put it, they will probably start Collins, Lehane and Horgan in Offaly.